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With its high output and flexible design features, the VHP M100X is one of the most versatile pharmaceutical grade Biodecontamination Units on the market today for applications requiring an integrated solution.


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Product Overview

STERIS' VHP M100X Open Loop System provides a flexible, safe, environmentally friendly method for continuous decontamination of larger spaces such as clean rooms, production filling line isolators, food and beverage lines, animal holding rooms, biological (BL2, BL3, BL4) safety labs, and pass-through chambers. The Open Loop is designed for “single-pass” peroxide injection and airflow. An Open-loop system can be integrated with the facility as a utility to produce shorter cycle times.


STERIS' VHP M100X Biodecontamination System utilizes Vaprox® Sterilant (EPA Reg. No. 58779-4) as a means of achieving dry, low temperature sterilization within large sealed enclosures such as cleanrooms and filling lines. The dry, gaseous process consists of four distinct phases:

Dehumidification - Humidity is removed from the room space via an integrated desiccant system. This is done to ensure that a true, dry biodecontamination process is achieved.

Conditioning - Vaprox is rapidly injected by the generator and converted into a dry vapor that quickly raises the level of hydrogen peroxide to an effective concentration.

Biodecontamination - Hydrogen peroxide vapor concentrations are maintained at the target concentration level to provide an effective kill of micro-organisms in the room space.

Aeration - The generator stops injecting Vaprox and accelerates the breakdown of vapor into its environmentally friendly base elements of water vapor and oxygen. Aeration continues until hydrogen peroxide is reduced to an acceptable level and the room is commissioned for regular use.


  • Productivity - Provides rapid decontamination for large spaces up to ~20,000ft3.
  • Flexibility - Provides continuous high capacity decontamination for production lines, material airlocks, isolator integration, etc.
  • Ease of Use - The open loop design is a fixed-in-place system integrated with an air handler system.
  • Efficacy - The gaseous decontamination process is effective against a wide variety of microorganisms and has a broad range of material compatibility.
  • Green - Provides a non-toxic and environmentally friendly alternative to other decontamination processes. Vaporized Hydrogen Peroxide breaks down to water vapor and Oxygen.


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