Rouging in Pharmaceutical and Biopharmaceutical Manufacturing Systems:

What, Why, Removal and Prevention

June 25, 2012 WEBINAR
12 pm - 1:30 pm EDT (New York Time)

Most pharmaceutical and biotech companies experience some corrosion and rouging of their stainless steel surfaces. Rouge can often be found in high purity water and steam systems as well as process equipment exposed to corrosive environments. There are several factors that can contribute to rouge formation including presence of halides, oxidizing chemistries, extreme pH's, high temperatures, dissimilar metallurgy or defects, improper welding, and inadequate passivation. This presentation will be divided into two parts: Part I will cover the different types of rouge, its formation, and industry practices for derouging and passivating stainless steel, this part will also provide some laboratory generated data (including XPS and Cr/Fe) demonstrating the characteristics and performance of derouging solutions. Part II will focus on presenting case studies including recommendations and procedures at different facilities.

During the webinar we will discuss the following:

Part I
- What is stainless steel?
- Passivation definitions and industry standards
- Nature, type and causes of rouge
- Solubility of iron oxides
- Routine “maintenance” derouging
- Issues to consider for manufacturing processes

Part II
- Several Case studies

$375 for one (1) person.
$700 for 2-5 people
$999 for 6-10 people

Instructor: Paul Lopolito

Paul Lopolito is a technical services manager for the Life Sciences Division of STERIS Corporation (Mentor, Ohio). He currently provides global technical support related to critical environment and process research cleaners, which includes field support, site audits, training presentations and educational seminars. Paul has over 15 years of industry experience and has held positions as a technical services manager, manufacturing manager and laboratory manager. Paul is a frequent speaker at industry events including the PDA, ISPE, INTERPHEX, AALAS, and IVT. Paul has published several articles and book-chapters related to cleaning and cleaning validation. He earned a B.A. in Biological Sciences from Goucher College in Towson, MD.