Whether it is a new laboratory research facility or renovation of an existing facility, a sound commissioning process is vital to start-up success. The commissioning process ensures that the facility and equipment within the facility are ready for occupancy and use. Additionally, it ensures compliance with federal, state, and local requirements. Part of this process includes a post-construction biodecontamination of the facility to ensure the safe integration of workers and animals into the new space. There are many factors that go into choosing the best method of biodecontamination including but not limited to size of the enclosure, ability to seal the enclosure, desired level of bioburden reduction, degree of process robustness, material compatibility, efficacy of the process, and environmental health and safety concerns.

This article discusses the successful use of hydrogen peroxide vapor in the biodecontamination of a new 120,000+ ft3 lab animal research facility for the purpose of a facility commissioning process.1It will discuss the reasons why this process was chosen; the preparation of the facility; the execution of the biodecontamination; and the results.

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