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VHP M100 Biodecontamination Systems Closed Loop

An all-in-one hydrogen peroxide vapor generator for pharmaceutical-grade biodecontamination in medical and biological laboratories that’s efficient in closed-loop configurations.

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Product Overview

STERIS' VHP® M100 Biodecontamination Systems: Closed Loop provide a flexible, safe, environmentally friendly method of decontamination to small, sealed enclosures.


STERIS VHP M100 Biodecontamination System utilizes Vaprox® Sterilant (EPA Reg. No. 58779-4) as a means of achieving dry, low temperature sterilization within sealed enclosures such as isolators and glove boxes. The dry, gaseous process consists of four distinct phases:

Dehumidification - Humidity is removed from the enclosure via an integrated desiccant system. This is done to ensure that a true, dry biodecontamination process is achieved.

Conditioning - Vaprox is rapidly injected by the generator and converted into a dry vapor that quickly raises the level of hydrogen peroxide to an effective concentration.

Biodecontamination - Hydrogen peroxide vapor concentrations are maintained at the target concentration level to provide an effective kill of micro-organisms in the enclosure.

Aeration - The generator stops injecting Vaprox and accelerates the breakdown of vapor into its environmentally friendly base elements of water vapor and oxygen. Aeration continues until hydrogen peroxide is reduced to an acceptable level.


  • Productivity - Provides rapid biodecontamination for small enclosures up to 70ft3.
  • Flexibility - Unit can be mobile or integrated into an isolator or biosafety cabinet.
  • Easy to Validate - GAMP Compliant.
  • Efficacy - The gaseous decontamination process is effective against a wide variety of microorganisms and has a broad range of material compatibility.
  • Green - Provides a non-toxic and environmentally friendly alternative to other decontamination processes. Vaporized Hydrogen Peroxide breaks down to water vapor and Oxygen.

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